The Oldest Hospital Still Active in the City
Founded in 1288, Santa Maria Nuova is the oldest hospital in Florence still in continuous operation. Located in the historic center, it represents a rare convergence of medieval charity, Renaissance medicine, art, architecture, and institutional innovation.
More than a hospital, Santa Maria Nuova is a living archive of Florence’s social history — where faith, finance, and medical science intersected centuries before modern healthcare systems emerged.
Who Founded Santa Maria Nuova?
Santa Maria Nuova was founded on June 23, 1288, by Folco Portinari, a wealthy Florentine merchant and banker.
Banking in the 13th century was considered morally risky. Lending money at interest was often associated with sin and usury. For elite families, philanthropy was not only generosity — it was spiritual investment.
Folco Portinari is also known as the father of Beatrice Portinari, widely identified as Dante’s muse in The Divine Comedy.
The Role of Monna Tessa
Florentine tradition credits Monna Tessa, the pious nurse of Beatrice, with inspiring the hospital’s foundation. Though partly legendary, she is historically associated with the creation of the Oblate Sisters, women devoted to hospital care.
The Oblate Sisters are considered among the earliest structured nursing communities in Europe — centuries before Florence Nightingale.
Remarkably, the Oblates were formally recognized only in 1953, which allowed them to survive earlier religious suppressions. Their presence has remained continuous since the 13th century.
How Santa Maria Nuova Changed Medieval Healthcare
When it opened, the hospital had just 12 beds, often shared by multiple patients. Yet even in its earliest form, it introduced important innovations:
- Separation of male and female wards
- Structured nursing roles
- Administrative record keeping
- Integration of spiritual and physical care
Unlike many medieval institutions that functioned mainly as shelters, Santa Maria Nuova was founded explicitly as a place of cure.
This distinction made it unique in 14th-century Florence.
The Impact of the Black Death
The Black Death of 1348 devastated Florence. Yet paradoxically, it strengthened Santa Maria Nuova.
Many citizens left bequests to the hospital in their wills. Historical records indicate that the institution received approximately 25,000 gold florins, enabling major expansion.
Within a century, Santa Maria Nuova became one of Italy’s most important medical centers.
Architecture Designed for Healing
The hospital’s original ward design reflected medieval medical beliefs.
Beds were placed along the walls of a large hall, facing a central altar. Patients could see devotional imagery from their beds. Healing was considered inseparable from spiritual reflection.
High windows were installed to reduce “miasmas,” based on the belief that disease spread through corrupted air.
A large wooden crucifix reminded patients of Christ’s suffering — encouraging meditation as part of recovery.
This architectural model influenced hospital design across Europe.
The Spedalingo: A Powerful Hospital Director
The hospital director, known as the spedalingo, held lifetime appointment and considerable authority.
In the 15th century, Pope Martin V visited and reconsecrated the hospital, publicly reaffirming its privileges. Frescoes by artists such as Gherardo di Giovanni commemorate this moment, depicting the spedalingo in a position of civic importance.
Santa Maria Nuova functioned as a large-scale institution:
- It owned approximately 30 rural farms
- It produced agricultural goods
- It generated surplus income
- It managed assets like a financial enterprise
The hospital operated with economic sophistication similar to Florence’s banking families.
Renaissance Medicine and Leonardo da Vinci
During the Renaissance, Santa Maria Nuova became an important site for medical study.
By the 15th and 16th centuries, the hospital employed salaried physicians and surgeons — marking a shift toward professional medicine.
Leonardo da Vinci conducted anatomical dissections here. He later left 400 ducats to the hospital in his will.
His anatomical studies represent a turning point in empirical medical observation.
The Spezieria: Florence’s Medical and Artistic Laboratory
The hospital’s apothecary (spezieria) was documented by the 14th century.
Medicines included:
- Herbal preparations
- Oils and balms
- Mineral compounds
- Ground gemstones
Painters belonged to the guild of Medici e Speziali (Doctors and Apothecaries), since pigments and medicines overlapped in materials.
The Compagnia di San Luca, an association of artists that included figures such as Lorenzo Ghiberti, had connections to this environment.
Santa Maria Nuova became a meeting point between art, science, and commerce.
Medicine, Magic, and the Mandrake
Medieval medicine mixed empirical knowledge with superstition.
The hospital’s herb gardens included plants such as:
- Mandrake, believed to possess magical properties
- Sage, valued for oral health
- Rue, used medicinally
- Florentine iris, later used in perfumery
The mandrake root, due to its human-like shape, was believed to contain a spirit. Extraction rituals involved tying it to a dog to avoid direct contact — a belief documented in medieval herbals.
Such practices illustrate Florence’s intellectual transition from superstition to scientific method.
Mental Health and Early Psychiatry
In the late 18th century, Santa Maria Nuova was linked to the Hospital of San Bonifazio, which treated chronic illness, skin diseases, and mental disorders.
Under the Grand Duchy of Lorraine, Florence became home to one of Europe’s earliest psychiatric institutions.
Before this period, individuals with mental illness were often imprisoned rather than treated.
The connection between dermatology and psychiatry was influenced by the spread of syphilis, which could begin with skin symptoms and progress neurologically.
This early medical awareness contributed to Florence’s later dermatological school.
The Franciscan Tau Symbol
The hospital’s emblem resembles a crutch but is actually a Tau cross, associated with the Franciscans.
The symbol represented healing — both physical and spiritual — and would have been immediately recognized by medieval Florentines.
Today, that symbolic literacy has largely disappeared.
Why Santa Maria Nuova Still Matters
Santa Maria Nuova survived:
- The Black Death
- Medici rule
- Napoleonic reforms
- Italian unification
- The 1966 Florence flood
Few institutions in Europe demonstrate such continuity.
It reveals a Florence not only of art and banking, but of structured care and civic responsibility.
The Renaissance was not born only in studios and palaces.
It was also shaped in hospital wards, botanical gardens, and apothecaries — where the human body became worthy of organized care

